Dushanbe (Tajik: Душанбе, Dushanbe; Dyushambe until 1929, Stalinabad until 1961), population 679,400 people (2008 est.), is the capital and largest city of Tajikistan. Dushanbe means "Monday" in Tajik, and the name reflects the fact that the city grew on the site of a village that originally was a popular Monday marketplace.

Situated on the confluence of two rivers, Varzob and Kofarnihon, Dushanbe is the capital of Tajikistan. Although archaeological remnants dating to the 5th century BC have been discovered in the area, there is little to suggest that Dushanbe was more than a small village until around 80 years ago. In 1920, the last Emir of Bukhara briefly took refuge in Dushanbe (then called Dyushambe) after being overthrown by the Bolshevik revolution. He fled to Afghanistan after the Red Army conquered the area the next year.

Dushanbe, which means "Monday" in Tajik, developed on the site of a Monday marketplace village, Dyushambe-Bozor, and its former name Dyushambe was a Russified version of the word meaning "Monday" in Tajik (du-shanbe from du two + shanbe Saturday, lit. "second day after Saturday"). Following the Red Army victory in Central Asia the village was upgraded to town in 1925 and made the capital of the newly created Tajik Autonomous Soviet Socialist Republic (Tajik ASSR). After the transformation of Tajik ASSR to Tajik Soviet Socialist Republic (Tajik SSR) in 1929, Dyushambe was renamed Stalinabad, after Joseph Stalin. As part of Nikita Khrushchev's de-Stalinization initiative, the city was renamed Dushanbe in 1961.

The Soviets transformed the area into a centre for cotton and silk production, and relocated tens of thousands of people to the city from around the Soviet Union. The population also increased with thousands of ethnic Tajiks migrating to Tajikistan following the transfer of Bukhara and Samarkand to the Uzbek SSR. A peaceful and relatively prosperous city under Soviet rule, Dushanbe was home to a university and the Tajik Academy of Sciences. Severe rioting occurred in February 1990, after it was rumored that Moscow planned to relocate tens of thousands of Armenian refugees to Tajikistan. Dushanbe riots were primarily fueled by concerns about housing shortages for the Tajik population, but they coincided with a wave of nationalist unrest that swept Transcaucasia and other Central Asian states during the twilight of Gorbachev's era.

The city was badly damaged as a result of the Civil War in Tajikistan (1992–1997) that sprang up in the nation shortly after its independence. However resurgences in the Tajik economy have transformed Dushanbe into a rapidly growing commercial, cultural and industrial center. Many multi-story apartment and office buildings were constructed and the city was beautified during this period. Monuments and statues commemorating the city's Persian and Iranian past were erected.