Kulob (Tajik/Persian:Кӯлоб/کولاب, for swampy place, rushes), also Kulab or Kulyab (Russian: Куляб), is a city in Kulob district, Khatlon Province, Tajikistan. Located 203 km south-east of the capital Dushanbe on the Yakhsu River (a right tributary of Panj), it is one of the largest cities in the country (pop. 82,000 in 2003).

Kulob is the birthplace of the current President of Tajikistan Emomali Rahmonov, Canadian media entrepreneur Moses Znaimer, and popular Tajik singers Manija Dawlatova and Shabnam Surayo.

Part of the Khanate of Bukhara since the 16th century (the Emirate of Bukhara since the 18th century), the city changed its name from Khatlon to Kulob in 1750. In 1921, after the fall of the Bukhara Emirate, Soviet rule was established in Kulob and the city became an industrial center during the Soviet era.

In September 2006 Kulob celebrated its 2700th anniversary. Shabnam Soraya sang a tribute to the city at the celebrations.