50 litas coin issued to commemorate the 600th Anniversary of  the settling down of Karaims and Tatars in Lithuania

In 1392 Grand Duke Vytautas of the Grand Duchy of Lithuania relocated one branch the Crimean Karaites to Lithuania where they continued to speak their own language. The Lithuanian Karaites settled primarily in Vilnius (Vilna) and Trakai (Troki), as well as in Biržai, Pasvalys, Naujamiestis and Upytė - smaller settlements throughout Lithuania proper - and lands of modern Belarus and Ukraine, that were part of the Grand Duchy of Lithuania. The Karaims in Lithuanian territory were granted a measure of autonomy.

Kenesa in VilniusSome famous Karaim scholars in Lithuania included Isaac b. Abraham of Troki (1543 - 1598), Joseph ben Mordecai Malinovski, Zera ben Nathan of Trakai, Salomon ben Aharon of Trakai, Ezra ben Nissan (died in 1666) and Josiah ben Judah (died after 1658). Some of the Karaim became quite wealthy.

During the times of the Polish-Lithuanian Commonwealth, the Karaims suffered severely during the Chmielnicki Uprising of 1648 and the wars between Russia and Poland in the years 1654-­1667, when many towns were plundered and burnt, including Trakai, where in 1680 only 30 families were left. Catholic missionaries made serious attempts to convert the local Karaims to Christianity, but ultimately were largely unsuccessful. The local Karaim communities still exist in Lithuania (where they live mostly in Panevėžys and Trakai regions) and Poland. The 1979 census in the USSR showed 3,300 Karaims. Lithuanian Karaim Culture Community was founded in 1988.

According to the Lithuanian Karaims website the Statistics Department of Lithuania carried out an ethno-statistic research "Karaim in Lithuania" in 1997. It was decided to question all adult Karaims and mixed families, where one of the members is a Karaim. During the survey, for the beginning of 1997, there were 257 Karaim nationality people, 32 of which were children under 16.

The Lipka Tatars (also known as Polish Tatars, Belarusian Tatars, Lithuanian Tatars, Lipkowie, Lipcani or Muślimi) are a group of Tatars who originally settled in the Grand Duchy of Lithuania at the beginning of 14th century. The first settlers tried to preserve their shamanistic religion and sought asylum amongst the non-Christian Lithuanians. Towards the end of the 14th century, another wave of Tatars - this time, Muslims and Karaite Jews - were invited into the Grand Duchy by Vytautas the Great. These Tatars first settled around Vilnius, Trakai, Hrodna and Kaunas and later spread to other parts of the Grand Duchy that later became part of Polish Lithuanian Commonwealth. These areas comprise present-day Lithuania, Belarus and Poland. From the very beginning of their settlement in Lithuania the Muslim Tatars were known as the Lipka Tatars. While maintaining their religion, they united their fate with that of the mainly Christian Polish-Lithuanian Commonwealth. From the Battle of Grunwald onwards the Lipka Tatar light cavalry regiments participated in every significant military campaign of Lithuania and Poland.

The Lipka Tatar origins can be traced back to the descendant states of the Mongol Empire of Genghis Khan - the White Horde, the Golden Horde, the Crimean Khanate and Kazan Khanate. They initially served as a noble military caste but later they became urban-dwellers known for their crafts, horses and gardening skills. Throughout centuries they resisted assimilation and kept their traditional lifestyle. While they remained very attached to their religions, over time however, they lost their original Tatar language and for the most part adopted Polish. There are still small groups of Lipka Tatars living in today's Belarus, Lithuania, Ukraine and Poland, as well as their communities in United States and Canada.